【学术交流】2026年第56期—— The cellular and molecular choreography of integrin adhesion dynamics in dividing cells

题 目：The cellular and molecular choreography of integrin adhesion dynamics in dividing cells

主讲人：Reinhard Fässler教授，德国马克斯.普朗克生物化学研究所

主持人：周中军教授 基础医学院首席科学家

时 间：2026年11月4日（星期三）15:00

地 点：科技大楼D栋一楼会议室

主 办：科学技术部、学报编辑部、基础医学院、广东省医学免疫与分子诊断重点实验室

参加人员：基础医学院、广东省医学免疫与分子诊断重点实验室教师、学生

欢迎广大师生前往交流！

科学技术部 学报编辑部 基础医学院

广东省医学免疫与分子诊断重点实验室

2026年 11月2日

专家介绍：

Reinhard Fässler教授

德国马克斯.普朗克生物化学研究所荣誉所长，分子医学系主任

Present position: Director Emeritus

Max Planck Institute of Biochemistry, Germany

Distinguished Affiliated Professor

Technical University of Munich

Reinhard Fassler教授是德国Max Planck生物化学研究所的名誉所长，分子医学系主任，德国科学院院士，奥地利科学院院士，欧洲分子生物学EMBO 院士。是国际著名发育生物学专家，Integrin领域国际一流专家。 荣获Max Kade Fellowship Award; Austrian Academy of Sciences; Hoechst Prize; Hermann and Lilly Schilling Award; Göran Gustafsson Prize of Swedish Academy of Sciences; Raine Visting Professorship of University of Western Australia; Honorary Professor, Medical Faculty, Copenhagen University; Distinguished Investigator Prize of the International Society of Matrix Biology; ERC Advanced Grant Award; Mok Hing-Yiu Distinguished Visiting Professorship of University of Hong Kong; Flexner Discovery Lecture, Vanderbilt University Medical Center; Main State Science Prize, Vorarlberg, Austria; ERC Synergy Grant Award; Medal Award of the British Society of Matrix Biology.

Reinhard Fassler教授发表了340篇学术论文和60多篇综述，书籍章节等。

主要科研论文包括：

Hirsch E., Iglesias A., Potocnik A., Hartmann U., and Fässler R. (1996). Migration but not differentiation of blood cells is dependent on the presence of β1 integrin. Nature, 380: 171-175.

Pfeifer A., Aszodi A., Seidler U., Ruth P., Hofmann F., and Fässler R. (1996). Mice lacking cyclic GMP-dependent kinase II are resistant to E. coli heat-stable enterotoxin STa and show skeletal abnormalities. Science, 274: 2082-2086.

Sakai T., Johnson K.J., Murozono M., Sakai K., Magnuson M.A., Wieloch T., Cronberg T., Isshiki A., Erickson H.P., and Fässler R. (2001). Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin wound healing and hemostasis. Nature Medicine, 7: 324 - 330.

Massoumi R., Chmielarska K., Hennecke K., Pfeifer A., and Fässler R. (2006). Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-κB signaling. Cell, 125: 665-677.

Krueger M., Moser M., Ussar S., Thievessen I., Luber C., Forner F., Schmidt S., Zanivan S., Fässler R., and Mann M. (2008). SILAC-mouse for quantitative proteome analysis uncovers Kindlin-3 as an essential factor for red blood cell function. Cell, 134: 353-364.

Lämmermann T., Bader B.L., Monkley S. J., Worbs T., Wedlich-Söldner R., Hirsch K., Keller M., Förster R., Critchley D.R., Fässler R., Sixt M. (2008). Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature, 453: 51-55.

Moser M., Nieswandt B., Ussar S., Pozgajova M., and Fässler R. (2008). Kindlin-3 is essential for integrin activation and platelet aggregation. Nature Medicine, 14: 325-330.

Moser M., Bauer M., Schmid S., Ruppert R., Schmidt S., Sixt M., Wang H.-V., Sperandio M., and Fässler R. (2009). Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells. Nature Medicine, 15: 300-305.

Böttcher R.T., Stremmel C., Meves A., Meyer H., Widmaier M., Tseng H.-Y., and Fässler R. (2012). Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1 integrin tail. Nature Cell Biol., 14: 584-592.

Schiller H.B., Hermann M.R., Polleux J., Vignaud T., Zanivan S., Friedel C.C., Sun Z., Raducanu A., Gottschalk K., Thery M., Mann M., and Fässler R. (2013). β1- and αv-class integrins cooperate to regulate myosin-II during rigidity sensing of fibronectin-based microenvironments. Nature Cell Biol., 15: 625-635.

Rognoni E., Widmaier M., Jakobson M., Ruppert R., Ussar S., Katsougkri D., Böttcher R.T., Lai-Cheong J.E., Rifkin D.B., McGrath J., and Fässler R. (2014). Kindlin-1 controls cutaneous epithelial stem cell proliferation by modulating Wnt ligand and TGFβ availability. Nature Med., 20: 350-359.

Sun Z., Tseng H.-Y., Tan S., Senger F., Kurzawa L., Dedden D., Mizuno N., Wasik A.A., Thery M., Dunn A.R., and Fässler R. (2016). Kank family proteins activate Talin and reduce force transduction across integrins. Nature Cell Biol., 18: 941-953.

Chen N.-P., Aretz J., and Fässler R. (2022). CDK1-cyclin B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry. Nature Cell Biol., 24: 723-736. doi: 10.1038/s41556-022-00886-z.

Aretz J., Aziz M., Strohmeyer N., Sattler M., and Fässler R. (2023). Talin and kindlin associate to promote ternary complex formation with integrins. Nature Struct. Mol. Biol., 30:1913-1924. doi: 10.1038/s41594-023-01139-9

主要综述论文包括：

Brakebusch, C., and Fässler, R. (2003). The integrin-actin connection, an eternal love affair. EMBO J., 22: 2324-2333.

Legate K.R., Montañez E., Kudlacek O., and Fässler R. (2006). ILK, PINCH and parvin: the tIPP of integrin signalling. Nature Rev. Mol. Cell Biol., 7: 20-31.

Moser M., Legate K.R., Zent R., and Fässler R. (2009). The tail of integrins, talin and kindlins. Science, 324: 895-899.

Wickström S.A., Lange A., Montanez E., and Fässler R. (2010). ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J., 29: 281-291.

Schiller H.B., and Fässler R. (2013). Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Reports, 14: 509-519.

Sun Z., Guo S.S., and Fässler R. (2016). Integrin-mediaed mechano-transduction. J. Cell Biol., 215: 445-446.

Sun Z., Costell M., and Fässler R. (2019). Integrin activation by talin, kindlin and mechanical forces. Nat Cell Biol., 21: 25-31.